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| WTA Finals Guadalajara | ||
| Surface: Hard | Date: Nov. 10 - Nov. 17 | Seed: 2 |
| Round | Opponent | W / L | Result |
| Round Robin | Anett Kontaveit | Loss | 3-6, 4-6 6-2, 3-6, 4-6 6-0, 4-6, 4-6 |
| Round Robin | Garbine Muguruza | Loss | 3-6, 4-6 6-2, 3-6, 4-6 6-0, 4-6, 4-6 |
| Round Robin | Karolina Pliskova | Loss | 3-6, 4-6 6-2, 3-6, 4-6 6-0, 4-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Zarina Diyas | Win | 6-4, 3-6, 6-1 |
| Third Round | Amanda Anisimova | Win | 6-2, 6-3 |
| Fourth Round | Paula Badosa | Loss | 1-6, 5-7 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Astra Sharma | Win | 6-0, 6-4 |
| Second Round | Christina McHale | Win | 6-3, 6-1 |
| Third Round | Kamilla Rakhimova | Win | 6-4, 6-2 |
| Fourth Round | Garbine Muguruza | Win | 6-3, 7-6 (7-4) |
| Quarterfinals | Aryna Sabalenka | Loss | 1-6, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Daria Kasatkina | Win | 6-3, 6-2 |
| Second Round | Dayana Yastremska | Win | 6-1, 7-6 (7-5) |
| Third Round | Garbine Muguruza | Win | 6-1, 6-7 (5-7), 6-2 |
| Quarterfinals | Ashleigh Barty | Loss | 2-6, 4-6 |
| Livesport Prague Open | ||
| Surface: Clay | Date: Jul. 12 - Jul. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Isabella Shinikova | Win | 6-2, 6-3 |
| Second Round | Ysaline Bonaventure | Win | 7-6 (7-2), 6-4 |
| Quarterfinals | Katerina Siniakova | Win | 6-3, 6-0 |
| Semifinals | Xinyu Wang | Win | 6-1, 6-2 |
| Final | Tereza Martincova | Win | 6-2, 6-0 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Clara Tauson | Win | 6-3, 6-2 |
| Second Round | Andrea Petkovic | Win | 7-5, 6-4 |
| Third Round | Anastasija Sevastova | Win | 7-6 (7-1), 3-6, 7-5 |
| Fourth Round | Ashleigh Barty | Loss | 5-7, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kristyna Pliskova | Win | 5-7, 6-4, 6-2 |
| Second Round | Ekaterina Alexandrova | Win | 6-2, 6-3 |
| Third Round | Elina Svitolina | Win | 6-3, 6-2 |
| Fourth Round | Sloane Stephens | Win | 6-2, 6-0 |
| Quarterfinals | Cori Gauff | Win | 7-6 (8-6), 6-3 |
| Semifinals | Maria Sakkari | Win | 7-5, 4-6, 9-7 |
| Final | Anastasia Pavlyuchenkova | Win | 6-1, 2-6, 6-4 |
| Internationaux de Strasbourg | ||
| Surface: Clay | Date: May 23 - May 29 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Oceane Dodin | Win | 6-3, 3-0 Retired |
| Second Round | Caroline Garcia | Win | 3-6, 6-2, 6-1 |
| Quarterfinals | Ekaterina Alexandrova | Win | 7-6 (7-4), 6-1 |
| Semifinals | Jule Niemeier | Win | 5-7, 6-3, 6-4 |
| Final | Sorana Cirstea | Win | 6-3, 6-3 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Saisai Zheng | Win | 6-2, 6-0 |
| Second Round | Sofia Kenin | Win | 6-1, 6-4 |
| Third Round | Iga Swiatek | Loss | 6-3, 6-7 (5-7), 5-7 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Paula Badosa | Loss | 1-6, 5-7 |
| Tennis Championship Istanbul | ||
| Surface: Red Clay | Date: Apr. 19 - Apr. 25 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Cagla Buyukakcay | Win | 6-7 (8-10), 6-2, 6-0 |
| Second Round | Ana Bogdan | Loss | 3-6, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anna Blinkova | Win | 6-1, 3-6, 6-3 |
| Second Round | Iga Swiatek | Loss | 4-6, 2-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Maria Sakkari | Win | 6-2, 7-6 (7-4) |
| Second Round | Jelena Ostapenko | Win | 6-3, 6-1 |
| Third Round | Svetlana Kuznetsova | Win | 6-3, 6-2 |
| Quarterfinals | Anastasia Potapova | Win | 6-0, 6-2 |
| Semifinals | Jil Teichmann | Win | 7-5, 6-2 |
| Final | Garbine Muguruza | Loss | 6-7 (6-8), 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Saisai Zheng | Win | 6-3, 2-6, 6-2 |
| Second Round | Ekaterina Alexandrova | Loss | 3-6, 6-7 (4-7) |
| Grampians Trophy | ||
| Surface: Hard | Date: Feb. 3 - Feb. 7 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Lauren Davis | Win | 6-4, 4-6, 6-4 |
| Second Round | Elena Rybakina | Win | 4-6, 6-2, 10-6 |
| Quarterfinals | Jennifer Brady | Loss | 6-7 (5-7), 4-6 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jamie Loeb | Win | 6-1, 6-3 |
| Second Round | Yulia Putintseva | Loss | 4-6, 5-7 |
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