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| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Benoit Paire |
| Open Parc Auvergne-Rhone-Alpes Lyon | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | David Goffin | Win | 6-3, 6-4 |
| Quarterfinals | Sebastian Baez | Win | 6-2, 2-6, 6-1 |
| Semifinals | Francisco Cerundolo | Loss | 3-6, 0-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexandre Muller | Win | 6-2, 6-3 |
| Third Round | Marton Fucsovics | Win | 6-2, 7-6 (7-4) |
| Fourth Round | Novak Djokovic | Loss | 3-6, 4-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yosuke Watanuki | Win | 6-4, 7-6 (7-5) |
| Third Round | Zhizhen Zhang | Loss | 6-2, 6-7 (2-7), 6-7 (2-7) |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pavel Kotov | Win | 6-1, 6-2 |
| Third Round | Lorenzo Musetti | Loss | 6-3, 4-6, 1-6 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Francisco Cerundolo | Loss | 3-6, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gregoire Barrere | Loss | 3-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tung-lin Wu | Win | 6-2, 6-4 |
| Third Round | Taro Daniel | Win | 6-7 (5-7), 7-5, 6-2 |
| Fourth Round | Andrey Rublev | Win | 6-2, 6-4 |
| Quarterfinals | Frances Tiafoe | Loss | 4-6, 4-6 |
| Rio Open presented by Claro | ||
| Surface: Clay | Date: Feb. 20 - Feb. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Juan Manuel Cerundolo | Win | 7-5, 6-1 |
| Second Round | Thiago Monteiro | Win | 7-5, 7-5 |
| Quarterfinals | Hugo Dellien | Win | 4-6, 6-1, 6-4 |
| Semifinals | Bernabe Zapata Miralles | Win | 6-2, 3-6, 7-6 (7-3) |
| Final | Carlos Alcaraz | Win | 5-7, 6-4, 7-5 |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 13 - Feb. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Facundo Diaz Acosta | Win | 4-6, 7-5, 7-6 (8-6) |
| Quarterfinals | Tomas Martin Etcheverry | Win | 5-7, 6-0, 6-3 |
| Semifinals | Juan Pablo Varillas | Win | 7-6 (7-5), 6-4 |
| Final | Carlos Alcaraz | Loss | 3-6, 5-7 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Luca Van Assche | Win | |
| Second Round | Constant Lestienne | Win | |
| Third Round | Jiri Lehecka | Loss |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jiri Lehecka | Win | |
| Quarterfinals | Marcos Giron | Win | |
| Semifinals | Jenson Brooksby | Win | |
| Final | Richard Gasquet | Loss |
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