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| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Lorenzo Musetti | Win | 5-7, 4-6, 6-2, 6-3, 6-2 |
| Second Round | Zdenek Kolar | Win | 6-3, 7-6 (10-8), 6-7 (3-7), 7-6(9-7) |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Grigor Dimitrov | Win | 6-3, 5-7, 7-6 (7-4) |
| Third Round | Karen Khachanov | Win | 4-6, 6-0, 6-3 |
| Quarterfinals | Jannik Sinner | Win | 7-6 (7-5), 6-2 |
| Semifinals | Alexander Zverev | Win | 4-6, 6-3, 6-3 |
| Final | Novak Djokovic | Loss | 0-6, 6-7 (5-7) |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lucas Pouille | Win | 6-3, 6-4 |
| Third Round | Grigor Dimitrov | Win | 6-3, 6-4 |
| Quarterfinals | Andrey Rublev | Win | 6-3, 2-6, 6-4 |
| Semifinals | Alexander Zverev | Loss | 4-6, 6-3, 2-6 |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ilya Ivashka | Win | 6-1, 4-6, 6-2 |
| Third Round | Grigor Dimitrov | Win | 6-1, 6-4 |
| Quarterfinals | Carlos Alcaraz | Loss | 4-6, 7-5, 2-6 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 10 - Apr. 17 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Fabio Fognini | Win | 6-3, 6-0 |
| Third Round | Laslo Djere | Win | 7-5, 7-6 (7-1) |
| Quarterfinals | Diego Schwartzman | Win | 6-2, 6-7 (3-7), 6-4 |
| Semifinals | Alexander Zverev | Win | 6-4, 6-2 |
| Final | Alejandro Davidovich Fokina | Win | 6-3, 7-6 (7-3) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | J.J. Wolf | Win | 6-4, 6-7 (5-7), 6-1 |
| Third Round | Alex De Minaur | Win | 6-4, 6-3 |
| Fourth Round | Carlos Alcaraz | Loss | 5-7, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jack Sock | Win | 7-6 (7-5), 3-6, 7-6 (7-5) |
| Third Round | Jenson Brooksby | Loss | 6-1, 3-6, 2-6 |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 21 - Feb. 26 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Laslo Djere | Win | 7-6 (9-7), 7-6 (7-4) |
| Second Round | J.J. Wolf | Win | 6-1, 6-0 |
| Quarterfinals | Marcos Giron | Win | 6-3, 6-4 |
| Semifinals | Cameron Norrie | Loss | 4-6, 4-6 |
| Open 13 Provence | ||
| Surface: Hard | Date: Feb. 14 - Feb. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Hugo Gaston | Win | 6-3, 7-6 (7-4) |
| Quarterfinals | Roman Safiullin | Loss | 4-6, 4-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 7 - Feb. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Alejandro Davidovich Fokina | Win | 7-5, 6-7 (1-7), 6-4 |
| Second Round | Ilya Ivashka | Win | 6-4, 6-1 |
| Quarterfinals | Alex De Minaur | Win | 6-4, 6-4 |
| Semifinals | Jiri Lehecka | Win | 4-6, 6-4, 6-2 |
| Final | Felix Auger-Aliassime | Loss | 4-6, 2-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Mikael Ymer | Win | 6-2, 6-4, 6-3 |
| Second Round | Sebastian Baez | Win | 7-6 (7-1), 6-7 (5-7), 6-3, 6-4 |
| Third Round | Benoit Paire | Win | 6-3, 7-5, 6-7 (2-7), 6-4 |
| Fourth Round | Taylor Fritz | Win | 4-6, 6-4, 4-6, 6-3, 6-4 |
| Quarterfinals | Jannik Sinner | Win | 6-3, 6-4, 6-2 |
| Semifinals | Daniil Medvedev | Loss | 6-7 (5-7), 6-4, 4-6, 1-6 |
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