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| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Daniel Elahi Galan | Loss | 0-6, 1-6, 6-3, 5-7 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Filip Krajinovic | Win | |
| Third Round | Diego Schwartzman | Win | |
| Quarterfinals | John Isner | Win | |
| Semifinals | Daniil Medvedev | Win | |
| Final | Borna Coric | Loss |
| Open de la Banque Nationale presentee par Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jack Draper | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Alexander Ritschard | Win | |
| Second Round | Jordan Thompson | Win | |
| Third Round | Nick Kyrgios | Loss |
| Mallorca Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ilya Ivashka | Win | |
| Quarterfinals | Marcos Giron | Win | |
| Semifinals | Benjamin Bonzi | Win | |
| Final | Roberto Bautista Agut | Win |
| Terra Wortmann Open | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Benjamin Bonzi | Win | |
| Second Round | Nick Kyrgios | Loss |
| BOSS OPEN | ||
| Surface: Grass | Date: Jun. 6 - Jun. 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dominic Stricker | Win | |
| Quarterfinals | Andy Murray | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Lorenzo Musetti | Win | |
| Second Round | Zdenek Kolar | Win | |
| Third Round | Mikael Ymer | Win | |
| Fourth Round | Holger Rune | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Grigor Dimitrov | Win | |
| Third Round | Karen Khachanov | Win | |
| Quarterfinals | Jannik Sinner | Win | |
| Semifinals | Alexander Zverev | Win | |
| Final | Novak Djokovic | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lucas Pouille | Win | |
| Third Round | Grigor Dimitrov | Win | |
| Quarterfinals | Andrey Rublev | Win | |
| Semifinals | Alexander Zverev | Loss |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ilya Ivashka | Win | |
| Third Round | Grigor Dimitrov | Win | |
| Quarterfinals | Carlos Alcaraz | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 10 - Apr. 17 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Fabio Fognini | Win | |
| Third Round | Laslo Djere | Win | |
| Quarterfinals | Diego Schwartzman | Win | |
| Semifinals | Alexander Zverev | Win | |
| Final | Alejandro Davidovich Fokina | Win |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | J.J. Wolf | Win | |
| Third Round | Alex De Minaur | Win | |
| Fourth Round | Carlos Alcaraz | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jack Sock | Win | |
| Third Round | Jenson Brooksby | Loss |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 21 - Feb. 26 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Laslo Djere | Win | |
| Second Round | J.J. Wolf | Win | |
| Quarterfinals | Marcos Giron | Win | |
| Semifinals | Cameron Norrie | Loss |
| Open 13 Provence | ||
| Surface: Hard | Date: Feb. 14 - Feb. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Hugo Gaston | Win | |
| Quarterfinals | Roman Safiullin | Loss |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 7 - Feb. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Alejandro Davidovich Fokina | Win | |
| Second Round | Ilya Ivashka | Win | |
| Quarterfinals | Alex De Minaur | Win | |
| Semifinals | Jiri Lehecka | Win | |
| Final | Felix Auger-Aliassime | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Mikael Ymer | Win | |
| Second Round | Sebastian Baez | Win | |
| Third Round | Benoit Paire | Win | |
| Fourth Round | Taylor Fritz | Win | |
| Quarterfinals | Jannik Sinner | Win | |
| Semifinals | Daniil Medvedev | Loss |
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