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| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Sebastian Ofner | Win | 6-2, 6-4, 6-4 |
| Second Round | Sebastian Baez | Win | 2-6, 4-6, 6-1, 6-2, 7-5 |
| Third Round | Brandon Nakashima | Win | 7-6 (7-2), 6-3, 7-6 (7-5) |
| Fourth Round | Bernabe Zapata Miralles | Win | 7-6 (13-11), 7-5, 6-3 |
| Quarterfinals | Carlos Alcaraz | Win | 6-4, 6-4, 4-6, 7-6(9-7) |
| Semifinals | Rafael Nadal | Loss | 6-7 (8-10), 6-6 Retired |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sebastian Baez | Win | 7-6 (8-6), 6-3 |
| Third Round | Alex De Minaur | Win | 6-3, 7-6 (7-5) |
| Quarterfinals | Cristian Garin | Win | 7-5, 6-2 |
| Semifinals | Stefanos Tsitsipas | Loss | 6-4, 3-6, 3-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marin Cilic | Win | 4-6, 6-4, 6-4 |
| Third Round | Lorenzo Musetti | Win | 6-3, 1-0 Retired |
| Quarterfinals | Felix Auger-Aliassime | Win | 6-3, 7-5 |
| Semifinals | Stefanos Tsitsipas | Win | 6-4, 3-6, 6-2 |
| Final | Carlos Alcaraz | Loss | 3-6, 1-6 |
| BMW Open by American Express | ||
| Surface: Red Clay | Date: Apr. 25 - May 1 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Holger Rune | Loss | 3-6, 2-6 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 10 - Apr. 17 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Federico Delbonis | Win | 6-1, 7-5 |
| Third Round | Pablo Carreno Busta | Win | 6-2, 7-5 |
| Quarterfinals | Jannik Sinner | Win | 5-7, 6-3, 7-6 (7-5) |
| Semifinals | Stefanos Tsitsipas | Loss | 4-6, 2-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Borna Coric | Win | 6-4, 3-6, 6-3 |
| Third Round | Mackenzie McDonald | Win | 6-2, 6-2 |
| Fourth Round | Thanasi Kokkinakis | Win | 6-4, 6-4 |
| Quarterfinals | Casper Ruud | Loss | 3-6, 6-1, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tommy Paul | Loss | 2-6, 6-4, 6-7 (2-7) |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 21 - Feb. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Jenson Brooksby | Win | 3-6, 7-6 (12-10), 6-2 |
| Second Round | Peter Gojowczyk | Loss | Retired |
| Open Sud de France | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Win | 6-2, 7-6 (7-5) |
| Quarterfinals | Adrian Mannarino | Win | 6-1, 6-0 |
| Semifinals | Mikael Ymer | Win | 6-1, 6-3 |
| Final | Alexander Bublik | Loss | 4-6, 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Daniel Altmaier | Win | 7-6 (7-3), 6-1, 7-6 (7-1) |
| Second Round | John Millman | Win | 6-4, 6-4, 6-0 |
| Third Round | Radu Albot | Win | 6-3, 6-4, 6-4 |
| Fourth Round | Denis Shapovalov | Loss | 3-6, 6-7 (5-7), 3-6 |
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