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| Hengqin Life WTA Elite Trophy | ||
| Surface: Hard | Date: Oct. 22 - Oct. 27 | Seed: 1 |
| Round | Opponent | W / L | Result |
| Round Robin | Donna Vekic | Win | 7-6 (7-5), 6-2 |
| VTB Kremlin Cup | ||
| Surface: Hard | Date: Oct. 14 - Oct. 20 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kaia Kanepi | Win | 4-6, 6-3, 7-5 |
| Quarterfinals | Kristina Mladenovic | Loss | 4-6, 6-2, 1-6 |
| Upper Austria Ladies Linz | ||
| Surface: Hard | Date: Oct. 7 - Oct. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Misaki Doi | Win | 6-4, 7-5 |
| Second Round | Alison Van Uytvanck | Win | 4-6, 6-3, 6-3 |
| Quarterfinals | Cori Gauff | Loss | 6-7 (1-7), 4-6 |
| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 6 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Donna Vekic | Win | 3-6, 6-1, 7-6 (7-3) |
| Second Round | Dayana Yastremska | Win | 7-6 (7-5), 6-3 |
| Third Round | Polona Hercog | Win | 7-6 (8-6), 2-6, 6-3 |
| Quarterfinals | Elina Svitolina | Win | 7-6 (8-6), 6-2 |
| Semifinals | Ashleigh Barty | Loss | 3-6, 6-3, 6-7 (7-9) |
| Dongfeng Motor Wuhan Open | ||
| Surface: Hard | Date: Sep. 22 - Sep. 28 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Bernarda Pera | Win | 3-6, 6-4, 6-2 |
| Third Round | Aryna Sabalenka | Loss | 1-6, 6-7 (9-11) |
| Toray Pan Pacific Open | ||
| Surface: Decoturf | Date: Sep. 16 - Sep. 22 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Pavlyuchenkova | Loss | 1-6, 5-7 |
| Zhengzhou Open | ||
| Surface: Hard | Date: Sep. 9 - Sep. 15 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ajla Tomljanovic | Loss | 4-6, 6-7 (1-7) |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Paula Badosa | Win | 6-4, 6-2 |
| Second Round | Anastasia Pavlyuchenkova | Win | 7-5, 6-4 |
| Third Round | Julia Goerges | Loss | 2-6, 3-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Venus Williams | Loss | 3-6, 6-3, 6-7 (4-7) |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Francesca Di Lorenzo | Win | 6-2, 6-1 |
| Third Round | Bianca Andreescu | Loss | 1-6, 7-6 (9-7), 4-6 |
| Internazionali Femminili di Palermo | ||
| Surface: Red Clay | Date: Jul. 22 - Jul. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Ekaterine Gorgodze | Win | 6-0, 6-1 |
| Second Round | Aleksandra Krunic | Win | 6-3, 6-1 |
| Quarterfinals | Jasmine Paolini | Win | 6-4, 1-6, 6-1 |
| Semifinals | Paula Badosa Gibert | Win | 6-1, 7-5 |
| Final | Jil Teichmann | Loss | 6-7 (3-7), 2-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Mandy Minella | Win | 6-3, 6-2 |
| Second Round | Taylor Townsend | Win | 3-6, 7-6 (7-5), 6-2 |
| Third Round | Barbora Strycova | Loss | 5-7, 1-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 23 - Jun. 29 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yulia Putintseva | Win | 6-4, 6-1 |
| Third Round | Anna-Lena Friedsam | Win | 6-3, 6-3 |
| Quarterfinals | Aryna Sabalenka | Win | 6-4, 3-6, 6-4 |
| Semifinals | Karolina Pliskova | Loss | 1-6, 2-6 |
| Libema Open | ||
| Surface: Grass | Date: Jun. 10 - Jun. 16 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Johanna Larsson | Win | 6-3, 6-1 |
| Second Round | Arantxa Rus | Win | 7-5, 6-3 |
| Quarterfinals | Natalia Vikhlyantseva | Win | 6-3, 6-3 |
| Semifinals | Elena Rybakina | Win | 6-4, 6-4 |
| Final | Alison Riske | Loss | 6-0, 6-7 (3-7), 5-7 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Pauline Parmentier | Win | 6-3, 6-4 |
| Second Round | Viktoria Kuzmova | Loss | 1-3 Retired |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Amanda Anisimova | Win | 6-2, 4-6, 7-5 |
| Third Round | Carla Suarez Navarro | Win | 6-4, 1-6, 6-3 |
| Quarterfinals | Naomi Osaka | Win | Retired |
| Semifinals | Johanna Konta | Loss | 7-5, 5-7, 2-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Katerina Siniakova | Win | 6-3, 6-2 |
| Second Round | Jelena Ostapenko | Win | 6-4, 6-3 |
| Third Round | Anastasija Sevastova | Win | 6-1, 6-2 |
| Quarterfinals | Petra Kvitova | Win | 6-2, 6-3 |
| Semifinals | Sloane Stephens | Win | 6-2, 7-5 |
| Final | Simona Halep | Win | 6-4, 6-4 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Anna-Lena Friedsam | Win | 7-5, 6-2 |
| Second Round | Belinda Bencic | Win | 4-6, 6-3, 6-4 |
| Quarterfinals | Angelique Kerber | Win | 6-3, 6-4 |
| Semifinals | Petra Kvitova | Loss | 6-7 (3-7), 6-3, 1-6 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 1 - Apr. 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Martina Trevisan | Win | 6-2, 6-1 |
| Third Round | Maria Sakkari | Loss | 6-7 (8-10), 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Xiyu Wang | Win | 6-4, 6-1 |
| Third Round | Viktoria Kuzmova | Win | 3-6, 6-0, 6-1 |
| Fourth Round | Ashleigh Barty | Loss | 6-4, 3-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magda Linette | Win | 6-4, 6-1 |
| Third Round | Johanna Konta | Win | 7-6 (12-10), 6-4 |
| Fourth Round | Garbine Muguruza | Loss | 7-5, 1-6, 4-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Viktoria Kuzmova | Loss | 2-6, 6-4, 6-7 (6-8) |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 11 - Feb. 16 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Camila Giorgi | Win | 0-6, 7-6 (9-7), 6-4 |
| Second Round | Carla Suarez Navarro | Win | 2-6, 6-1, 6-1 |
| Quarterfinals | Elise Mertens | Loss | 4-6, 3-6 |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Jan. 28 - Feb. 3 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ysaline Bonaventure | Win | 6-4, 6-2 |
| Quarterfinals | Anastasia Pavlyuchenkova | Win | 6-2, 3-6, 6-0 |
| Semifinals | Aryna Sabalenka | Win | 7-6 (7-5), 6-2 |
| Final | Donna Vekic | Win | 7-6 (7-2), 6-4 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Win | 6-3, 6-3 |
| Second Round | Anastasia Pavlyuchenkova | Loss | 6-3, 3-6, 3-6 |
| Sydney International | ||
| Surface: Hard | Date: Jan. 6 - Jan. 12 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bernarda Pera | Win | 7-5, 6-4 |
| Second Round | Garbine Muguruza | Win | Retired |
| Quarterfinals | Yulia Putintseva | Win | 6-2, 6-2 |
| Semifinals | Ashleigh Barty | Loss | 7-6 (7-4), 4-6, 5-7 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 31 - Jan. 6 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Elise Mertens | Win | 6-2, 6-7 (6-7), 6-4 |
| Second Round | Donna Vekic | Loss | 6-7 (5-7), 6-1, 5-7 |
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