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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Rebecca Peterson | Win | 6-0, 6-1 |
| Second Round | Daria Saville | Win | 6-3, 6-4 |
| Third Round | Kaja Juvan | Win | 6-0, 6-1 |
| Fourth Round | Jelena Ostapenko | Loss | 6-3, 3-6, 1-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Danielle Collins | Win | 6-1, 6-0 |
| Third Round | Qinwen Zheng | Win | 3-6, 6-1, 6-1 |
| Quarterfinals | Marketa Vondrousova | Win | 7-6 (7-3), 6-1 |
| Semifinals | Coco Gauff | Loss | 6-7 (2-7), 6-3, 4-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Karolina Pliskova | Win | 7-6 (8-6), 6-2 |
| Third Round | Karolina Muchova | Win | 6-1, 4-6, 6-4 |
| Quarterfinals | Danielle Collins | Win | 6-3, 4-6, 6-2 |
| Semifinals | Jessica Pegula | Loss | 2-6, 7-6 (7-4), 4-6 |
| BNP Paribas Poland Open | ||
| Surface: Clay | Date: Jul. 24 - Jul. 30 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Nigina Abduraimova | Win | 6-4, 6-3 |
| Second Round | Claire Liu | Win | 6-2, 6-2 |
| Quarterfinals | Linda Noskova | Win | 6-1, 6-4 |
| Semifinals | Yanina Wickmayer | Win | 6-1, 7-6 (8-6) |
| Final | Laura Siegemund | Win | 6-0, 6-1 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 15 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Lin Zhu | Win | |
| Second Round | Sara Sorribes Tormo | Win | |
| Third Round | Petra Martic | Win | |
| Fourth Round | Belinda Bencic | Win | |
| Quarterfinals | Elina Svitolina | Loss |
| Bad Homburg Open presented by Engel & Volkers | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Tatjana Maria | Win | |
| Second Round | Jil Teichmann | Win | |
| Quarterfinals | Anna Blinkova | Win | |
| Semifinals | Lucia Bronzetti | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 10 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Cristina Bucsa | Win | |
| Second Round | Claire Liu | Win | |
| Third Round | Xinyu Wang | Win | |
| Fourth Round | Lesia Tsurenko | Win | |
| Quarterfinals | Coco Gauff | Win | |
| Semifinals | Beatriz Haddad Maia | Win | |
| Final | Karolina Muchova | Win |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 21 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Pavlyuchenkova | Win | |
| Third Round | Lesia Tsurenko | Win | |
| Fourth Round | Donna Vekic | Win | |
| Quarterfinals | Elena Rybakina | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 25 - May 6 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Julia Grabher | Win | |
| Third Round | Bernarda Pera | Win | |
| Fourth Round | Ekaterina Alexandrova | Win | |
| Quarterfinals | Petra Martic | Win | |
| Semifinals | Veronika Kudermetova | Win | |
| Final | Aryna Sabalenka | Loss |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Qinwen Zheng | Win | |
| Quarterfinals | Karolina Pliskova | Win | |
| Semifinals | Ons Jabeur | Win | |
| Final | Aryna Sabalenka | Win |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Claire Liu | Win | |
| Third Round | Bianca Andreescu | Win | |
| Fourth Round | Emma Raducanu | Win | |
| Quarterfinals | Sorana Cirstea | Win | |
| Semifinals | Elena Rybakina | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Leylah Fernandez | Win | |
| Third Round | Liudmila Samsonova | Win | |
| Semifinals | Coco Gauff | Win | |
| Final | Barbora Krejcikova | Loss |
| Qatar Total Energies Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Danielle Collins | Win | |
| Quarterfinals | Belinda Bencic | Win | |
| Semifinals | Veronika Kudermetova | Win | |
| Final | Jessica Pegula | Win |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Jule Niemeier | Win | |
| Second Round | Camila Osorio | Win | |
| Third Round | Cristina Bucsa | Win | |
| Fourth Round | Elena Rybakina | Loss |
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