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| European Open | ||
| Surface: Hard | Date: Oct. 18 - Oct. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andy Murray | Win | 6-4, 7-6 (8-6) |
| Quarterfinals | Brandon Nakashima |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Maxime Cressy | Win | 6-2, 3-6, 7-5 |
| Third Round | Daniel Evans | Win | 5-7, 6-4, 6-0 |
| Fourth Round | Casper Ruud | Win | 6-3, 6-3 |
| Quarterfinals | Cameron Norrie | Loss | 0-6, 2-6 |
| San Diego Open | ||
| Surface: Hard | Date: Sep. 27 - Oct. 3 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Federico Gaio | Win | 6-2, 6-3 |
| Second Round | Lloyd Harris | Win | 4-6, 6-3, 6-2 |
| Quarterfinals | Andrey Rublev | Loss | 1-6, 5-7 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Ricardas Berankis | Win | 7-5, 6-3, 6-3 |
| Second Round | Kevin Anderson | Win | 7-6 (7-4), 6-3, 6-4 |
| Third Round | Alex Molcan | Win | 6-4, 6-3, 6-3 |
| Fourth Round | Botic van de Zandschulp | Loss | 3-6, 4-6, 7-5, 7-5, 1-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Daniel Evans | Win | 6-2, 4-6, 6-3 |
| Second Round | Frances Tiafoe | Win | 6-1, 4-6, 6-4 |
| Third Round | Casper Ruud | Loss | 4-6, 3-6 |
| Open de la Banque Nationale presentee par Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Benoit Paire | Win | 7-5, 6-1 |
| Third Round | Roberto Bautista Agut | Loss | 3-6, 6-3, 5-7 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Benoit Paire | Win | 6-3, 6-4, 6-0 |
| Second Round | Liam Broady | Win | 4-6, 6-2, 6-1, 6-4 |
| Third Round | Marton Fucsovics | Loss | 3-6, 3-6, 7-6 (8-6), 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Yen-Hsun Lu | Win | 6-2, 6-2, 6-3 |
| Second Round | Aljaz Bedene | Win | 6-4, 6-2, 6-4 |
| Third Round | Philipp Kohlschreiber | Win | 6-4, 6-2, 6-1 |
| Fourth Round | Jan-Lennard Struff | Win | 7-6 (11-9), 6-4, 7-5 |
| Quarterfinals | Rafael Nadal | Loss | 3-6, 6-4, 4-6, 0-6 |
| Open Parc Auvergne-Rhone-Alpes Lyon | ||
| Surface: Clay | Date: May 17 - May 23 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Richard Gasquet | Loss | 3-6, 5-7 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Felix Auger-Aliassime | Loss | 1-6, 3-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aslan Karatsev | Loss | 6-2, 4-6, 1-6 |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 19 - Apr. 25 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Frances Tiafoe | Win | 3-6, 7-5, 6-1 |
| Third Round | Corentin Moutet | Win | 6-4, 6-2 |
| Quarterfinals | Pablo Carreno Busta | Loss | 4-6, 6-3, 5-7 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 11 - Apr. 18 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Casper Ruud | Loss | 3-6, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yasutaka Uchiyama | Win | 6-3, 6-3 |
| Third Round | Adrian Mannarino | Win | 6-1, 6-4 |
| Fourth Round | Sebastian Korda | Loss | 3-6, 6-4, 5-7 |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Mar. 15 - Mar. 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Lorenzo Musetti | Loss | 3-6, 6-2, 4-6 |
| Argentina Open | ||
| Surface: Clay | Date: Mar. 1 - Mar. 7 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lukas Klein | Win | 6-4, 6-2 |
| Quarterfinals | Jaume Munar | Win | 6-2, 7-5 |
| Semifinals | Miomir Kecmanovic | Win | 6-0, 6-4 |
| Final | Francisco Cerundolo | Win | 6-1, 6-2 |
| Cordoba Open | ||
| Surface: Red Clay | Date: Feb. 22 - Feb. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marco Cecchinato | Win | 6-2, 6-2 |
| Quarterfinals | Albert Ramos-Vinolas | Loss | 1-6, 6-4, 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Elias Ymer | Win | 7-6 (7-3), 6-4, 2-6, 6-2 |
| Second Round | Alexandre Muller | Win | 6-2, 6-0, 6-3 |
| Third Round | Aslan Karatsev | Loss | 3-6, 3-6, 3-6 |
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