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| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Flavio Cobolli | Win | 6-0, 6-2, 7-5 |
| Second Round | Taro Daniel | Win | 6-1, 3-6, 6-1, 6-2 |
| Third Round | Denis Shapovalov | Win | 6-1, 6-4, 6-2 |
| Fourth Round | Lorenzo Musetti | Win | 6-3, 6-2, 6-2 |
| Quarterfinals | Stefanos Tsitsipas |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Albert Ramos-Vinolas | Win | 6-4, 6-1 |
| Third Round | Fabian Marozsan | Loss | 3-6, 6-7 (4-7) |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Emil Ruusuvuori | Win | 2-6, 6-4, 6-2 |
| Third Round | Grigor Dimitrov | Win | 6-2, 7-5 |
| Fourth Round | Alexander Zverev | Win | 6-1, 6-2 |
| Quarterfinals | Karen Khachanov | Win | 6-4, 7-5 |
| Semifinals | Borna Coric | Win | 6-4, 6-3 |
| Final | Jan-Lennard Struff | Win | 6-4, 3-6, 6-3 |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nuno Borges | Win | 6-3, 6-1 |
| Third Round | Roberto Bautista Agut | Win | 6-3, 7-5 |
| Quarterfinals | Alejandro Davidovich Fokina | Win | 7-6 (7-5), 6-4 |
| Semifinals | Daniel Evans | Win | 6-2, 6-2 |
| Final | Stefanos Tsitsipas | Win | 6-3, 6-4 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Facundo Bagnis | Win | 6-0, 6-2 |
| Third Round | Dusan Lajovic | Win | 6-0, 7-6 (7-5) |
| Fourth Round | Tommy Paul | Win | 6-4, 6-4 |
| Quarterfinals | Taylor Fritz | Win | 6-4, 6-2 |
| Semifinals | Jannik Sinner | Loss | 7-6 (7-4), 4-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thanasi Kokkinakis | Win | 6-3, 6-3 |
| Third Round | Tallon Griekspoor | Win | 7-6 (7-4), 6-3 |
| Fourth Round | Jack Draper | Win | 6-2, 2-0 Retired |
| Quarterfinals | Felix Auger-Aliassime | Win | 6-4, 6-4 |
| Semifinals | Jannik Sinner | Win | 7-6 (7-4), 6-3 |
| Final | Daniil Medvedev | Win | 6-3, 6-2 |
| Rio Open presented by Claro | ||
| Surface: Clay | Date: Feb. 20 - Feb. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Mateus De Carvalho Cardoso Alves | Win | 6-4, 6-4 |
| Second Round | Fabio Fognini | Win | 6-7 (5-7), 6-2, 6-4 |
| Quarterfinals | Dusan Lajovic | Win | 6-4, 7-6 (7-0) |
| Semifinals | Nicolas Jarry | Win | 6-7 (2-7), 7-5, 6-0 |
| Final | Cameron Norrie | Loss | 7-5, 4-6, 5-7 |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 13 - Feb. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Laslo Djere | Win | 6-2, 4-6, 6-2 |
| Quarterfinals | Dusan Lajovic | Win | 6-4, 6-2 |
| Semifinals | Bernabe Zapata Miralles | Win | 6-2, 6-2 |
| Final | Cameron Norrie | Win | 6-3, 7-5 |
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