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| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Mikael Ymer | Win | 7-5, 6-2, 6-4 |
| Second Round | Alexander Shevchenko | Win | 6-1, 6-1, 6-2 |
| Third Round | Cameron Norrie |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Matteo Arnaldi | Win | 6-4, 6-4 |
| Third Round | Frances Tiafoe | Win | 5-7, 6-4, 6-3 |
| Fourth Round | Stefanos Tsitsipas | Loss | 5-7, 5-7 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yannick Hanfmann | Loss | 4-6, 6-7 (3-7) |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jason Kubler | Win | 6-3, 6-1 |
| Third Round | Cameron Norrie | Win | 3-6, 6-4, 6-1 |
| Quarterfinals | Jannik Sinner | Win | Retired |
| Semifinals | Stefanos Tsitsipas | Loss | 4-6, 7-5, 3-6 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Miomir Kecmanovic | Win | 7-6 (7-1), 6-0 |
| Second Round | Luca Nardi | Win | 6-0, 6-0 |
| Third Round | Novak Djokovic | Win | 4-6, 7-5, 6-4 |
| Quarterfinals | Jannik Sinner | Loss | 2-6, 2-6 |
| Grand Prix Hassan II | ||
| Surface: Red Clay | Date: Apr. 3 - Apr. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Hugo Gaston | Win | 6-2, 6-3 |
| Quarterfinals | Alexandre Muller | Loss | 3-6, 6-1, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jiri Lehecka | Loss | 4-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Adrian Mannarino | Loss | 4-6, 4-6 |
| Chile Dove Men+Care Open | ||
| Surface: Clay | Date: Feb. 27 - Mar. 5 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jaume Munar | Loss | 4-6, 4-6 |
| Rio Open presented by Claro | ||
| Surface: Clay | Date: Feb. 20 - Feb. 26 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Nicolas Jarry | Loss | 4-6, 1-6 |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 13 - Feb. 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pedro Cachin | Win | 6-2, 6-3 |
| Quarterfinals | Juan Pablo Varillas | Loss | 4-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Lloyd Harris | Loss |
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