Roster
| Num | Name | Pos | Exp | Ht | Wt | Born | Birthplace | College |
| 56 | Kwon Alexander | LB | 5 | 6-1 | 227 | 8/3/1994 | Oxford, AL | LSU |
| 50 | Joey Alfieri | LB | R | 6-2 | 226 | 3/6/1996 | Stanford | |
| 51 | Azeez Al-Shaair | LB | R | 6-2 | 228 | 8/4/1997 | Florida Atlantic | |
| 65 | Kofi Amichia | G | 1 | 6-3 | 305 | 7/29/1994 | East Point, GA | South Florida |
| 91 | Arik Armstead | DT | 5 | 6-7 | 290 | 11/15/1993 | Sacramento, CA | Oregon |
| 64 | Alex Barrett | DE | 1 | 6-2 | 250 | 3/6/1994 | Yuma, AZ | San Diego State |
| 3 | C.J. Beathard | QB | 3 | 6-2 | 215 | 11/16/1993 | Franklin, TN | Iowa |
| 98 | Ronald Blair III | DT | 4 | 6-4 | 270 | 1/21/1993 | Greensboro, NC | Appalachian State |
| 97 | Nick Bosa | DE | R | 6-4 | 266 | 10/23/1997 | Ohio State | |
| 84 | Kendrick Bourne | WR | 3 | 6-1 | 190 | 8/4/1995 | Portland, OR | Eastern Washington |
| 22 | Matt Breida | RB | 3 | 5-11 | 195 | 2/28/1995 | Brandon, FL | Georgia Southern |
| Jake Brendel | C | 4 | 6-4 | 299 | 9/10/1992 | Madison, WI | UCLA | |
| 60 | Daniel Brunskill | T | 1 | 6-5 | 300 | 1/27/1994 | San Diego, CA | San Diego State |
| 99 | DeForest Buckner | DT | 4 | 6-7 | 295 | 3/17/1994 | Waianae, HI | Oregon |
| 88 | Garrett Celek | TE | 8 | 6-5 | 252 | 5/29/1988 | Cincinnati, OH | Michigan State |
| 78 | Shon Coleman | T | 4 | 6-5 | 310 | 11/25/1991 | Memphis, TN | Auburn |
| 26 | Tevin Coleman | RB | 5 | 6-1 | 210 | 4/16/1993 | Tinley Park, IL | Indiana |
| 96 | Sheldon Day | DT | 4 | 6-1 | 285 | 7/1/1994 | Indianapolis, IN | Notre Dame |
| 82 | Ross Dwelley | TE | 2 | 6-5 | 235 | 1/26/1995 | Sonora, CA | San Diego |
| Chris Edwards | S | 1 | 6-1 | 218 | 12/23/1992 | Dallas, TX | Idaho | |
| 45 | Demetrius Flannigan-Fowles | LB | R | 6-2 | 210 | 9/4/1996 | Arizona | |
| 55 | Dee Ford | DE | 6 | 6-2 | 252 | 3/19/1991 | Odenville, AL | Auburn |
| 63 | Ben Garland | G | 6 | 6-5 | 304 | 4/6/1988 | Grand Junction, CO | Air Force |
| 10 | Jimmy Garoppolo | QB | 6 | 6-2 | 225 | 11/2/1991 | Arlington Heights, IL | Eastern Illinois |
| 90 | Kevin Givens | DT | R | 6-1 | 285 | 3/1/1997 | Penn State | |
| 11 | Marquise Goodwin | WR | 7 | 5-9 | 185 | 11/19/1990 | Lubbock, TX | Texas |
| 9 | Robbie Gould | K | 15 | 6-0 | 190 | 12/6/1982 | Jersey Shore, PA | Penn State |
| 57 | Dre Greenlaw | LB | R | 6-0 | 227 | 5/25/1997 | Arkansas | |
| 36 | Marcell Harris | S | 2 | 6-0 | 208 | 6/9/1994 | Florida | |
| 35 | Tim Harris Jr. | CB | R | 6-1 | 205 | 7/31/1995 | Virginia | |
| 43 | Daniel Helm | TE | R | 6-4 | 255 | 4/20/1995 | Duke | |
| Willie Henry Jr. | DT | 4 | 6-3 | 288 | 3/20/1994 | Cleveland, OH | Michigan | |
| 17 | Jalen Hurd | WR | R | 6-4 | 230 | 1/23/1996 | Baylor | |
| 13 | Richie James Jr. | WR | 2 | 5-9 | 185 | 9/5/1995 | Middle Tennessee State | |
| 35 | Dontae Johnson | CB | 6 | 6-2 | 200 | 12/1/1991 | Pennington, NJ | North Carolina State |
| 93 | D.J. Jones | DT | 3 | 6-0 | 305 | 1/19/1995 | Greenville, SC | Mississippi |
| 71 | Jaryd Jones-Smith | T | R | 6-7 | 345 | 9/3/1995 | Pittsburgh | |
| 44 | Kyle Juszczyk | RB | 7 | 6-1 | 235 | 4/23/1991 | Medina, OH | Harvard |
| 48 | Jermaine Kelly | CB | 2 | 6-1 | 204 | 2/26/1995 | San Jose State | |
| Derrick Kindred | S | 4 | 5-10 | 208 | 12/15/1993 | TCU | ||
| 85 | George Kittle | TE | 3 | 6-4 | 250 | 10/9/1993 | Madison, WI | Iowa |
| Jonathan Kongbo | LB | R | 6-5 | 255 | 3/19/1996 | Surrey, Canada | Tennessee | |
| 64 | Andrew Lauderdale | T | 1 | 6-6 | 291 | 11/22/1993 | New Hampshire | |
| 47 | Elijah Lee | LB | 3 | 6-2 | 229 | 2/8/1996 | St. Joseph, MO | Kansas State |
| 81 | Jordan Matthews | WR | 6 | 6-3 | 215 | 7/16/1992 | Madison, AL | Vanderbilt |
| 69 | Mike McGlinchey | T | 2 | 6-8 | 310 | 1/12/1995 | Notre Dame | |
| 28 | Jerick McKinnon | RB | 6 | 5-9 | 205 | 5/3/1992 | Atlanta, GA | Georgia Southern |
| 93 | Earl Mitchell | DT | 10 | 6-3 | 310 | 9/25/1987 | Houston, TX | Arizona |
| 90 | Damontre Moore | DE | 6 | 6-4 | 260 | 9/11/1992 | DeSoto, TX | Texas A&M |
| 33 | Tarvarius Moore | S | 2 | 6-2 | 200 | 8/16/1996 | Southern Miss | |
| 41 | Emmanuel Moseley | CB | 2 | 5-11 | 190 | 3/25/1996 | Greensboro, NC | Tennessee |
| 31 | Raheem Mostert | RB | 5 | 5-10 | 205 | 4/9/1992 | Smyrna Beach, FL | Purdue |
| 4 | Nick Mullens | QB | 2 | 6-1 | 210 | 3/21/1995 | Hoover, AL | Southern Miss |
| 86 | Kyle Nelson | TE | 8 | 6-2 | 240 | 10/3/1986 | Waco, TX | New Mexico State |
| 53 | Mark Nzeocha | LB | 5 | 6-3 | 235 | 1/19/1990 | Neusitz, West Germany | Wyoming |
| 68 | Mike Person | C | 9 | 6-4 | 305 | 5/17/1988 | Glendive, MT | Montana State |
| 18 | Dante Pettis | WR | 2 | 6-1 | 195 | 10/23/1995 | Washington | |
| 1 | Shawn Poindexter | WR | R | 6-5 | 213 | 12/13/1995 | Arizona | |
| 32 | D.J. Reed Jr. | CB | 2 | 5-9 | 193 | 11/11/1996 | Kansas State | |
| 76 | Ross Reynolds | G | R | 6-4 | 300 | 9/14/1995 | Iowa | |
| 58 | Weston Richburg | C | 6 | 6-4 | 290 | 7/9/1991 | Louisville, KY | Colorado State |
| 19 | Deebo Samuel | WR | R | 6-0 | 215 | 1/15/1996 | South Carolina | |
| 17 | Emmanuel Sanders | WR | 10 | 5-11 | 180 | 3/17/1987 | Bellville, TX | Southern Methodist |
| 25 | Richard Sherman | CB | 9 | 6-3 | 205 | 3/30/1988 | Compton, CA | Stanford |
| 67 | Justin Skule | T | R | 6-6 | 315 | 11/23/1996 | Vanderbilt | |
| 66 | Ray Smith | DT | R | 6-1 | 302 | 1/18/1997 | Boston College | |
| 74 | Joe Staley | T | 13 | 6-5 | 300 | 8/30/1984 | Rockford, MI | Central Michigan |
| 95 | Kentavius Street | DE | 1 | 6-2 | 287 | 5/8/1996 | North Carolina State | |
| 40 | Teez Tabor | CB | 3 | 6-0 | 201 | 12/31/1995 | Washington, DC | Florida |
| 29 | Jaquiski Tartt | S | 5 | 6-1 | 215 | 2/18/1992 | Mobile, AL | Samford |
| 77 | Jullian Taylor | DT | 2 | 6-5 | 305 | 1/30/1995 | Philadelphia, PA | Temple |
| 15 | Trent Taylor | WR | 3 | 5-8 | 180 | 4/30/1994 | Cookeville, TN | Louisiana Tech |
| 46 | Jacob Thieneman | S | R | 6-1 | 215 | 2/29/1996 | Purdue | |
| 94 | Solomon Thomas | DE | 3 | 6-3 | 280 | 8/26/1995 | Chicago, IL | Stanford |
| 89 | Chris Thompson | WR | 2 | 6-0 | 175 | 5/9/1994 | Florida | |
| 83 | Levine Toilolo | TE | 7 | 6-8 | 268 | 7/30/1991 | San Diego, CA | Stanford |
| 75 | Laken Tomlinson | G | 5 | 6-3 | 315 | 2/9/1992 | Jamaica | Duke |
| 27 | Jason Verrett | CB | 6 | 5-10 | 188 | 6/18/1991 | Fairfield, CA | TCU |
| 20 | Jimmie Ward | S | 6 | 5-11 | 195 | 7/18/1991 | Racine, WI | Northern Illinois |
| 54 | Fred Warner | LB | 2 | 6-3 | 230 | 11/19/1996 | Brigham Young | |
| 61 | Leonard Wester | T | 4 | 6-6 | 305 | 1/3/1993 | Mount Union, IA | Missouri Western State |
| 24 | K'Waun Williams | CB | 5 | 5-9 | 185 | 7/12/1991 | Paterson, NJ | Pittsburgh |
| 30 | Jeff Wilson Jr. | RB | 2 | 6-0 | 194 | 11/16/1995 | Elkhart, TX | North Texas |
| 6 | Mitch Wishnowsky | P | R | 6-2 | 220 | 3/3/1992 | Utah | |
| 23 | Ahkello Witherspoon | CB | 3 | 6-3 | 195 | 3/21/1995 | Oak Park, CA | Colorado |
| 92 | Anthony Zettel | DE | 4 | 6-4 | 275 | 8/9/1992 | Tawas City, MI | Penn State |
Head Coach: Kyle Shanahan
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