Roster
| Num | Name | Pos | Exp | Ht | Wt | Born | Birthplace | College |
| 11 | Brandon Aiyuk | WR | 3 | 6-0 | 200 | 3/17/1998 | Reno, NV | Arizona State |
| 51 | Azeez Al-Shaair | LB | 4 | 6-2 | 228 | 8/4/1997 | Florida Atlantic | |
| 91 | Arik Armstead | DT | 8 | 6-7 | 290 | 11/15/1993 | Sacramento, CA | Oregon |
| 65 | Aaron Banks | G | 2 | 6-5 | 325 | 9/3/1997 | Alameda, CA | Notre Dame |
| 97 | Nick Bosa | DE | 4 | 6-4 | 266 | 10/23/1997 | Ohio State | |
| 64 | Jake Brendel | C | 5 | 6-4 | 299 | 9/10/1992 | Madison, WI | UCLA |
| 60 | Daniel Brunskill | T | 4 | 6-5 | 300 | 1/27/1994 | San Diego, CA | San Diego State |
| 74 | Spencer Burford | G | R | 6-4 | 300 | 7/19/2000 | Texas-San Antonio | |
| 48 | Oren Burks | LB | 5 | 6-3 | 233 | 3/21/1995 | Vanderbilt | |
| 32 | Tyrion Davis-Price | RB | R | 6-1 | 219 | 10/23/2000 | Baton Rouge, LA | LSU |
| 82 | Ross Dwelley | TE | 5 | 6-5 | 235 | 1/26/1995 | Sonora, CA | San Diego |
| 56 | Samson Ebukam | DE | 6 | 6-3 | 245 | 5/9/1995 | Nigeria | Eastern Washington |
| 45 | Demetrius Flannigan-Fowles | LB | 3 | 6-2 | 223 | 9/4/1996 | Arizona | |
| 10 | Jimmy Garoppolo | QB | 9 | 6-2 | 225 | 11/2/1991 | Arlington Heights, IL | Eastern Illinois |
| 31 | Tashaun Gipson Sr. | S | 11 | 6-1 | 212 | 8/7/1990 | Dallas, TX | Wyoming |
| 90 | Kevin Givens | DT | 3 | 6-1 | 285 | 3/1/1997 | Penn State | |
| 9 | Robbie Gould | K | 18 | 6-0 | 190 | 12/6/1982 | Jersey Shore, PA | Penn State |
| 6 | Danny Gray | WR | R | 6-0 | 200 | 4/1/1999 | Ruston, LA | Southern Methodist |
| 57 | Dre Greenlaw | LB | 4 | 6-0 | 230 | 5/25/1997 | Arkansas | |
| 61 | Blake Hance | G | 2 | 6-6 | 310 | 1/11/1996 | Northwestern | |
| 29 | Talanoa Hufanga | S | 2 | 6-0 | 200 | 2/2/1999 | Corvallis, OR | USC |
| 92 | Kerry Hyder Jr. | DE | 7 | 6-2 | 275 | 5/2/1991 | Austin, TX | Texas Tech |
| 95 | Drake Jackson | DE | R | 6-4 | 273 | 4/12/2001 | USC | |
| 15 | Jauan Jennings | WR | 2 | 6-3 | 212 | 7/10/1997 | Cowan, TN | Tennessee |
| 44 | Kyle Juszczyk | RB | 10 | 6-2 | 235 | 4/23/1991 | Medina, OH | Harvard |
| 99 | Javon Kinlaw | DT | 3 | 6-5 | 319 | 10/3/1997 | Washington, DC | South Carolina |
| 85 | George Kittle | TE | 6 | 6-4 | 250 | 10/9/1993 | Madison, WI | Iowa |
| 81 | Tyler Kroft | TE | 8 | 6-6 | 252 | 10/15/1992 | Downingtown, PA | Rutgers |
| 38 | Deommodore Lenoir | CB | 2 | 5-10 | 200 | 10/6/1999 | Los Angeles, CA | Oregon |
| 25 | Marlon Mack | RB | 6 | 6-0 | 212 | 3/7/1996 | Sarasota, FL | South Florida |
| 24 | Jordan Mason | RB | R | 5-11 | 223 | 5/24/1999 | Gallatin, TN | Georgia Tech |
| 3 | Ray-Ray McCloud III | WR | 5 | 5-9 | 190 | 10/15/1996 | Clemson | |
| 69 | Mike McGlinchey | T | 5 | 6-8 | 310 | 1/12/1995 | Notre Dame | |
| 68 | Colton McKivitz | T | 3 | 6-6 | 301 | 8/9/1996 | Jacobsburg, OH | West Virginia |
| 76 | Jaylon Moore | T | 2 | 6-4 | 311 | 1/9/1998 | Western Michigan | |
| 33 | Tarvarius Moore | S | 5 | 6-2 | 200 | 8/16/1996 | Southern Miss | |
| 4 | Emmanuel Moseley | CB | 5 | 5-11 | 190 | 3/25/1996 | Greensboro, NC | Tennessee |
| 30 | George Odum | S | 5 | 6-1 | 202 | 11/3/1993 | Central Arkansas | |
| 94 | Charles Omenihu | DE | 4 | 6-5 | 280 | 8/20/1997 | Houston, TX | Texas |
| 46 | Taybor Pepper | C | 5 | 6-4 | 245 | 5/28/1994 | Michigan State | |
| 13 | Brock Purdy | QB | R | 6-1 | 220 | 12/27/1999 | Queen Creek, AZ | Iowa State |
| 98 | Hassan Ridgeway | DT | 7 | 6-3 | 305 | 11/2/1994 | Rodeo, CA | Texas |
| 19 | Deebo Samuel | WR | 4 | 6-0 | 215 | 1/15/1996 | South Carolina | |
| 20 | Ambry Thomas | CB | 2 | 6-0 | 190 | 9/9/1999 | Detroit, MI | Michigan |
| 53 | Kemoko Turay | DE | 5 | 6-5 | 253 | 7/11/1995 | Rutgers | |
| 7 | Charvarius Ward | CB | 5 | 6-1 | 196 | 5/16/1996 | Middle Tennessee State | |
| 54 | Fred Warner | LB | 5 | 6-3 | 230 | 11/19/1996 | Brigham Young | |
| 71 | Trent Williams | T | 13 | 6-5 | 320 | 7/19/1988 | Longview, TX | Oklahoma |
| 22 | Jeff Wilson Jr. | RB | 5 | 6-0 | 213 | 11/16/1995 | Elkhart, TX | North Texas |
| 18 | Mitch Wishnowsky | P | 4 | 6-2 | 220 | 3/3/1992 | Utah | |
| 89 | Charlie Woerner | TE | 3 | 6-5 | 241 | 10/16/1997 | Tiger, GA | Georgia |
| 26 | Samuel Womack III | CB | R | 5-10 | 189 | 7/7/1999 | Toledo | |
| 63 | Nick Zakelj | G | R | 6-6 | 316 | 6/22/1999 | Fordham |
Head Coach: Kyle Shanahan
Last updated Sep. 28, 5:26 p.m. ET
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